Notes on Aeschylus, Agamemnon 1437; 1163; 1172

Metatheatre in Aeschylus’ Oresteia

Lionel Abel coined the word ‘metatheatre’ in his 1963 book, Metatheatre: A New View of Dramatic Form, claiming he had discovered a new type of theatre, and cited Shakespeare’s Hamlet as the first metatheatrical play. Over the intervening decades, various scholars have pushed the incidence of the earliest metatheatrical play back beyond Hamlet. Richard Hornby, in his 1986 book, Drama, Metadrama,...

Sophrosyne in Aeschylus

Dmd051326 1163..1169

The role of pulmonary metabolism in trans-resveratrol (RES) pharmacokinetics was studied in a mouse model. Plasma concentrations of RES and its major metabolites trans-resveratrol-3-sulfate (R3S) and trans-resveratrol-3-glucuronide (R3G) were compared after administration of RES by intravenous (IV) and intra-arterial (IA) routes. Total area under the curve (AUC) of RES decreased by approximatel...

Dmd057000 1163..1173

Metabolism by cytochrome P4503A (CYP3A) is the most prevalent clearance pathway for drugs. Designation of metabolism by CYP3A commonly refers to the potential contribution by one or both of two enzymes, CYP3A4 and CYP3A5. The metabolic turnover of 32 drugs known to be largely metabolized by CYP3A was examined in human liver microsomes (HLMs) from CYP3A5 expressers (*1/*1 genotype) and nonexpres...

Dmd056887 1432..1437

This study was performed to identify genetic polymorphisms in multidrug and toxin extrusion 2-K (MATE2-K, SLC47A2), a proton/ organic cation antiporter that plays a role in the transport of organic cations across the apical membrane in kidney epithelial cells into the urine, and to demonstrate their effects on MATE2-K functions in vitro. Four of the thirty single nucleotide polymorphisms (SNPs)...